Duchenne muscular dystrophy is the most common terminal, childhood, genetic illness and at the same time is likely the most misunderstood condition. Recently, innovative research has uncovered many mysteries of Duchenne including its etiology, pathophysiology and treatment. As physical therapists and assistants, we continue to be one of the only treatment options for those who have Duchenne. It is vital that we have a thorough understanding of the disease and deliver appropriate treatments based on the current evidence. Inadequate understanding of the disease can lead to physical therapy related muscle injury to patients already at risk for severe muscle degeneration. Further education for physical therapists/assistants is crucial to our patients' lives. This course will explain the incidence, etiology, pathophysiology, progression and the stages of mobility of Duchenne. Physical therapy treatment, orthopedic management, activity modification and equipment selection will be covered. An update on current research and clinical trials will be provided to course participants.