This course will cover paradigms of pain science including the fundamentals of the peripheral, the spinal, and subcortical, and cortical processing of noxious and threatening stimuli. Physiological responses such as peripheral sensitization, central sensitization, and cortical changes associated with chronic pain will be discussed. Pain memory, biopsychosocial, and associative learning models will be discussed and integrated into the clinical treatment of patients. Current pain science topics will be integrated with clinical reasoning paradigms and used to assess and rehabilitate people in pain.