Extended immobility has been associated with medical complications during hospitalization and early mobilization after stroke is thought to contribute to the effect of stroke-unit care. The goal of this CEU course is to explore if upright positioning within 24 hours of stroke onset would be beneficial to patient outcome. In addition, because fatigue is a common complaint after stroke, this course investigates if fatigue prevalence in stroke patients is different to that of age and gender matched general population controls, and explores whether early motor activity is associated with reduced likelihood of fatigue three months after stroke.