Objectives: Following this lecture participants will: 1) Take the information from lecture one and integrate it into treatment principals 2) Understand the key differences between nociceptive dominant, peripheral neuropathic dominant, and central sensitization dominant pain presentations. 3) Have an introductory understanding how when and how to use neuroscience education and graded motor imagery in treatment 4) Have a functional understanding of how to apply graded exposure principals to centrally dominant patients.