Muscle injuries continue to form a large part of what physiotherapists see in clinical practice on a daily basis. It is important for the clinician to be aware of the latest research on this injury type, understand what progress has been made in the field, and be up to date with the latest clinical trends in the treatment of these injuries. Optimal loading is a key concept in how we understand modern rehabilitation and provide successful outcomes for our patients. Understanding the mechanism and the applied science of this approach is vital in creating optimal rehabilitation programmes. Furthermore, the role of the physiotherapist in the prevention of muscle injuries and keeping athletes healthy is an important consideration in the ever changing face of clinical medicine. The objective of this Masterclass is to provide clinicians with the necessary knowledge to understand and interpret research on muscle injuries, and integrate the research in daily practice to provide evidence based treatment.