This two-day course introduces information critical to the assessment and treatment of patients with acute, subacute, and chronic persistent pain. Translating pain mechanism research into clinical practice this course introduces to clinicians when to use a Pain Mechanism Approach versus a Pathoanatomical Approach. A pain mechanism approach allows classification and treatment of pain as it relates to the peripheral and central nervous system and it’s dominating factors to persistent symptoms. A Pain Mechanism Classification System (PMCS) will be outlined and serve to target selection of patient education and active care interventions for the dominating factors preventing full recovery allowing customization and individualization of care plans. The PMCS assessment will be demonstrated through live patient demonstrations, video, and paper case studies to aid application to clinicians’ practice. This course highlights a subgrouping framework, PMCS, which addresses pain from acute, subacute, and chronic stages covering chemical, structural, mechanical, cognitive, emotional, social, psychological, and cortical factors. This course integrates pain science research into a biopsychosocial dynamic approach utilizing breakout sessions for practical application of patient education and active care interventions. Promoting a common language toward recovery between pain clinicians of all disciplines and patients can transform rehabilitation interventions into patient self-assessment and prevention strategies. Included in this course, breakout sessions of active peripheral nervous system neurodynamic evaluation and treatment and central nervous system sensorimotor evaluation. The PMCS patient education and active care interventions support all patient ages and musculoskeletal to neurological diagnoses suffering from pain.