Course Description: The purpose of this online course is to provide an accessible, evidence-based framework for how to evaluate and successfully manage patients that have undergone regenerative medicine procedures so as to optimize clinical and patient-centered outcomes. In addition to reviewing the physiologic construct of typical regenerative medicine procedures (e.g., platelet rich and platelet poor plasma, adipose derived stem cell injections, bone marrow aspirate concentrate injections, and exosomes), the course provides recommendations based on clinical experience, patient preference, and the latest research for using graded exercise, manual therapy, functional medicine, and evidence-based technologies to optimize each phase of tissue healing. The course specifically provides didactic training on photobiomodulation (i.e., Class 3-4 laser), shockwave (i.e., radial and focused), electric modalities (i.e., multi-waveform NMES, electric dry needling, and noninvasive brain stimulation), and functional medicine (e.g. peptides, supplements, recovery, and sleep). While the use of these skills and technologies can be effectively applied to patients with neuromusculoskeletal conditions, the focus of this course will be how to use exercise, manual therapy, and evidence-based technologies to augment regenerative medicine procedures. The physiology and clinical rational for using the following rehabilitation technologies will be covered: - Photobiomodulation is a tool that helps balance mitochondria, thereby activating a number of cascades responsible for cellular proliferation, differentiation, migration, homeostasis, and repair. When photobiomodulation is improperly dosed, the treatment often fails to create physiologic change and/or drives the creation of dangerous reactive oxygen species, resulting in cellular damage and apoptosis. This class will review the physiologic mechanism behind photobiomodulation and determine how and when to administer it for various tissue types, neuromusculoskeletal disorders, and stages of tissue healing. The course will also consider photobiomodulation to optimize human performance. - Shockwave drives waves of energy in a manner that is either focused or dispersed throughout various physiologic tissue-types so as to mechanically stimulate cells, and thereby, initiate a number of cascades responsible for proliferation, differentiation, migration, homeostasis, and repair. When improperly dosed, shockwave may not drive enough energy to create a physiologic change. In contrast, excessive shockwave stimulation has the potential to drive inflammation, tissue damage, and cell death. The purpose of this class is to review the physiologic mechanism behind shockwave technology and recommend how and when to administer it for various tissue types, neuromusculoskeletal disorders, and stages of tissue healing. - Rehabilitation professionals have traditionally incorporated electric modalities such as transcutaneous electric stimulation, interferential current, neuromuscular electric stimulation, Russian stimulation, and micro-current in clinical practice so as to reduce pain, facilitate muscle contraction, and drive tissue repair. However, this class will consider multi-waveform technology to improve the effectiveness and efficiency of functional movement and exercise. In addition, the class will explore the physiologic effects of electric dry needling. Finally, the course will explore the use of noninvasive brain stimulation to rebalance excitation and inhibition in the central nervous system, thereby facilitating plastic changes associated with pain reduction and motor learning. - Rehabilitation professionals must consider peptides, supplements, and sleep principles to maximize tissue repair, recovery and performance.