Physical therapists are often the first point of contact for patients with musculoskeletal complaints, making it critical to recognize when a presentation suggests a condition beyond the scope of physical therapy. This session is designed to sharpen the physical therapy students' and clinicians’ ability to identify, interpret, and act on red flags that may indicate serious pathology. The session blends short lectures with interactive lab practice. Topics include red flag indicators for an array of body regions and systemic conditions. Through case-based scenarios and lab activities, attendees will apply clinical decision-making to help determine whether to treat, monitor, or refer. Participants will leave with an understanding of essential screening questions, increased confidence in triaging patients, and evidence-based strategies for integrating red flag screening into everyday practice.