This continuing education course provides physical therapists with the knowledge and clinical tools to effectively evaluate and treat individuals with cancer and cancer-related musculoskeletal conditions. Content includes identification of red flags for undiagnosed cancer, the therapist’s role in managing functional mobility impairments, and an overview of local and systemic side effects of treatment, including chemotherapy, radiation, gene therapy, and hormonal therapy. Special emphasis will be placed on cancer-related fatigue and essential safety precautions for this population. Participants will also review landmark research that has advanced the oncology specialty, providing an evidence-based foundation for practice. Using a systems-based approach, the course will outline assessment strategies, outcome measures, and rehabilitation considerations across the lymphatic, cardiopulmonary, neurological, musculoskeletal, genitourinary, gastrointestinal, and psychological systems. By the conclusion of this course, participants will gain strategies to improve safety, enhance functional outcomes, and promote quality of life for individuals affected by cancer throughout the continuum of care.